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Deep Tech Companies in Sheffield: 77 Active Firms (2026)
Deep tech companies in Sheffield commercialise science and engineering innovations across AI, advanced hardware, healthcare, energy and industrial systems.
Buying centres tend to sit in engineering, operations, clinical, energy and infrastructure teams rather than general IT, with procurement shaped by technical validation, safety cases and integration risk. Sheffield and nearby South Yorkshire vendors often sell to industrial operators, health and care organisations, energy and infrastructure buyers, research-intensive groups and public-sector teams. Engagements are rarely low-touch subscriptions: they more often involve specialist intellectual property, technical services, prototype-to-production engineering, regulated deployments or enterprise contracts. Sales cycles therefore tend to be longer than ordinary software procurement, with proof-of-concept work, standards evidence and deployment support carrying as much weight as the product itself.
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Sheffield’s cohort is small but visibly commercial: 77 companies are actively trading in the city and nearby South Yorkshire, with 5 reporting turnover above £5M and 14 incorporated since 2022. Reported headcount totals 413 people, which points to a market made up mainly of lean technical teams rather than large production workforces. The count also suggests a thin scale-up layer: a limited group have crossed the revenue threshold, while many remain in specialist services, project delivery or early repeatable-product stages.
Oversight does not sit under a unified UK deep-tech rulebook. It follows the use case: health deployments can bring MHRA considerations, personal-data-heavy AI or sensing systems sit near ICO guidance and GDPR, and cyber activity is tied to secure-by-design policy and the Cyber Security and Resilience Bill. Engineering biology has the Engineering Biology Regulators Network, sandboxes and the Genetic Technology (Precision Breeding) Act, while quantum and semiconductor activity is shaped more by national strategies, funding conditions and standards work than by licensing. For Sheffield suppliers, compliance evidence becomes part of commercial qualification, especially when selling into public-sector, healthcare or infrastructure buyers.
Near-term development appears likely to be uneven rather than broad-based. Sheffield has the ingredients for specialised engineering and industrial deployment, but deep-tech sales tend to depend on patient procurement, access to test environments and buyers willing to share integration risk. Healthcare, cyber and AI-adjacent firms will keep facing heavier evidence burdens as public bodies and regulated customers formalise procurement standards. Scale-up scarcity may encourage partnerships with industrial primes, universities and contract manufacturing partners, while consolidation is more likely around validated intellectual property and customer access than around simple roll-up economics.
77
Active firms
2026
5
Above £5M
reported turnover
14
Founded since 2022
Key facts
About 6% of the trading cohort reports turnover above £5M (5 of 77 firms) — the rest sits below that revenue band.
18% of the cohort was incorporated since 2022 (14 firms), so a sizeable share is in its first few filing cycles.
Deep tech is not a single regulated industry in the UK; oversight tends to follow the technology and use case.
Government policy treats advanced connectivity, AI, cyber security, engineering biology, quantum technologies and semiconductors as priority frontier technologies.
AI is being handled through a pro-innovation, sector-specific model rather than one cross-sector licensing regime.
Engineering biology is linked to the Engineering Biology Regulators Network, regulatory sandboxes and the Genetic Technology (Precision Breeding) Act.
UK deep tech venture investment has slowed from its 2021 peak but still “consistently attracts over £5 billion in annual venture capital”.
Top Sheffield Deep Tech companies
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsDevelops photonic quantum computing technology including single‑photon light sources, modular photonic hardware, rack‑mounted quantum computer systems and control software. Provides quantum computing…
Serves government, academic and industry partners, including organisations in aerospace, cybersecurity, defence, energy, pharmaceuticals and AI seeking scalable quantum computing capabilities.
Financial Health
StrongStrong · Growing, Hiring · 59% CAGR over 4y
Location
Chase Research Cryogenics Ltd
Trajectory
5y · 2020–NowFinancial sub-scores
Computed from 5 filingsDesigns and manufactures sub‑Kelvin cryogenic cooling systems, including sorption cryocoolers, miniature dilution refrigerators and gas‑gap heat switches, used in scientific and engineering…
Sells to scientific and engineering organisations, including research teams, labs and OEM partners needing sub-Kelvin cryogenic systems for applications in astrophysics, quantum technologies,…
Financial Health
StrongStrong · Hiring · 12% CAGR over 5y
Location
MACHINEWORKS LIMITED
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsDevelops software development toolkits for CNC machining simulation and 3D modelling. Provides libraries enabling material removal simulation, collision detection, machine tool simulation and…
Serves B2B industrial software and manufacturing technology companies, including CAD/CAM vendors, CNC controller makers, machine tool manufacturers, post-processing software providers and 3D printing…
Financial Health
WeakWeak · -68% CAGR over 4y
Location
Phlux
Trajectory
5y · 2022–NowFinancial sub-scores
Computed from 5 filingsDevelops and manufactures indium gallium arsenide (InGaAs) avalanche photodiode infrared sensors operating at 1550 nm. Supplies components and packaged devices for LiDAR systems, laser rangefinders,…
Serves OEMs and engineering teams building infrared sensing systems, including LiDAR, laser rangefinder, optical fibre test (OTDR) and fibre sensing equipment manufacturers.
Financial Health
StableStable · Hiring · 51% CAGR over 4y
Location
GOLD STANDARD PHANTOMS LIMITED
Trajectory
5y · 2022–NowFinancial sub-scores
Computed from 5 filingsDevelops and manufactures NIST‑traceable MRI calibration phantoms and quality assurance tools, and provides calibration services and automated QA systems used by research and clinical imaging…
Serves medical imaging researchers, academic institutions, hospitals, clinical radiology teams, imaging facilities, and multi-site clinical trial networks using quantitative MRI.
Financial Health
WeakWeak · -61% CAGR over 4y
Location
OCF Limited
Trajectory
3y · 2023–NowFinancial sub-scores
Computed from 3 filingsDesigns, implements and supports high‑performance computing (HPC), data storage and cloud infrastructure systems. Provides AI and deep learning platforms, consultancy, project management and managed…
Sells to organisations needing high-performance computing infrastructure, mainly B2B and research-sector buyers in higher education, life sciences, healthcare, engineering and manufacturing,…
Financial Health
WeakWeak · -89% CAGR over 2y
Location
PYROPTIK INSTRUMENTS LIMITED
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsProvides consultancy, design and supply of non‑contact optical measurement systems, including infrared temperature and fibre‑optic pyrometry, thermal imaging and hyperspectral imaging instruments for…
Serves industrial manufacturers and research/public-sector users in iron and steel, glass, petrochemicals, additive manufacturing, agriculture, environmental monitoring, glaciology, libraries and…
Financial Health
StableStable · Hiring · 63% CAGR over 4y
Location
Trajectory
2y · 2020–NowFinancial sub-scores
Computed from 2 filingsDevelops and manufactures scientific instruments and software for life science research, nuclear medicine and radiation safety. Products include radio‑TLC scanners, gamma spectrometry and radio‑HPLC…
Serves life science laboratories, radiopharmacies, PET/nuclear medicine departments, radiopharmaceutical companies and radiation safety teams in healthcare, research and industrial settings.
Financial Health
StableStable · 2% CAGR over 1y
Location
ADDITIVE MANUFACTURING TECHNOLOGIES LTD
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsManufactures and distributes post‑processing equipment for additive manufacturing. Produces precision machines used to clean, smooth, dye and finish 3D‑printed parts for industrial production…
Serves businesses producing 3D printed parts, including additive manufacturing service providers and industrial manufacturers needing post-processing equipment.
Financial Health
HealthyHealthy · -56% CAGR over 4y
Location
LIBERTINE FPE LIMITED
Trajectory
2y · 2020–NowFinancial sub-scores
Computed from 2 filingsDevelops linear generator and linear motor‑generator technologies and modular power systems. Provides platforms, test actuators and integration support for engine makers, powertrain companies and…
Serves B2B engine makers, powertrain companies, heat engine and gas compressor businesses, plus research organisations and demonstration pilot partners in distributed generation, EV recharging and…
Financial Health
WeakWeak · -10% CAGR over 1y
Location
Opteran Technologies Limited
Trajectory
4y · 2021–NowFinancial sub-scores
Computed from 4 filingsDevelops neuromorphic software for autonomous machines, modelling insect and animal brain processes to enable navigation and localisation. Provides software that allows robots and vehicles to operate…
Serves businesses developing or operating autonomous machines, including robotics OEMs and automation teams using AGVs, AMRs, drones, robotic arms, automotive platforms and humanoids.
Financial Health
StableStable · Hiring · 72% CAGR over 4y
Location
Faraday Scientific Limited
Trajectory
5y · 2020–NowFinancial sub-scores
Computed from 5 filingsDevelops application software, embedded firmware and electronic hardware for scientific and industrial instrumentation. Services include instrument control and data acquisition software, FPGA and…
Serves B2B organisations developing or using scientific and industrial instrumentation, including firms in physical, chemical, materials, forensic and biological sciences, and sectors such as…
Financial Health
StrongStrong · Hiring · 12% CAGR over 4y
Location
MANUFACTURING MADE EASY LTD
Trajectory
2y · 2023–NowFinancial sub-scores
Computed from 2 filingsDesigns and develops products for manufacture, providing concept development, design for manufacture, prototyping and production setup. Also builds custom modular laser powder bed fusion (L‑PBF) 3D…
Targets businesses and research organisations developing manufactured products, including engineering teams needing prototyping, industrial 3D printing and production scale-up.
Financial Health
StrongStrong · Growing, Hiring · 100% CAGR over 1y
Location
Trajectory
4y · 2022–NowFinancial sub-scores
Computed from 4 filingsDesigns and supplies laboratory equipment, testing systems and materials for research in thin‑film electronics, photovoltaics and electrochemistry, including spin coaters, slot‑die coaters, solar…
Serves academic, industrial and government research laboratories worldwide, especially materials science, thin-film electronics, photovoltaics, spectroscopy and electrochemistry researchers and R&D…
Financial Health
StrongStrong · Hiring · 15% CAGR over 3y
Location
LOGICATRONICS LIMITED
Trajectory
5y · 2020–NowFinancial sub-scores
Computed from 5 filingsFinancial Health
WeakWeak
Location
FLOREON TECHNOLOGY LIMITED
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsDevelops and supplies plant‑based PLA bioplastic materials for manufacturing, including flame‑retardant, durable and compostable grades. Materials are designed as drop‑in alternatives to…
Serves manufacturers, product designers and brands using injection moulding or extrusion who need plant-based plastic materials for durable, flame-retardant, food-contact, toy or compostable…
Financial Health
StrongStrong · Hiring · 11% CAGR over 4y
Location
AMODO DESIGN LTD
Trajectory
3y · 2023–NowFinancial sub-scores
Computed from 3 filingsProvides engineering design and development of hardware systems and scientific equipment. Combines mechanical, electronic, firmware and software engineering to build prototypes, research tools and…
Serves startups, universities, corporates and research funders needing advanced hardware expertise, particularly in scientific discovery, AI security, biosecurity and new materials.
Financial Health
StrongStrong · Hiring · 134% CAGR over 2y
Location
PRACTICAL CONTROL LIMITED
Trajectory
3y · 2022–NowFinancial sub-scores
Computed from 3 filingsDesigns and develops electronic products and embedded systems, including hardware, firmware and Internet of Things devices. Provides product engineering, prototyping and manufacturing support for…
Financial Health
HealthyHealthy · 0% CAGR over 2y
Location
Beamshape Limited
Trajectory
3y · 2023–NowFinancial sub-scores
Computed from 3 filingsDevelops electron beam melting (EBM) 3D printers that use high‑power electron beams to manufacture metal parts from powder. Also designs custom electron beam systems and electron‑optical software for…
Sells B2B to aerospace, medical, energy and defence organisations needing advanced metal additive manufacturing, plus semiconductor and life sciences partners seeking custom electron beam systems.
Financial Health
StrongStrong · Growing · 2% CAGR over 2y
Location
SCI SEMICONDUCTOR LIMITED
Trajectory
2y · 2024–NowFinancial sub-scores
Computed from 2 filingsFinancial Health
StableStable · Hiring · 100% CAGR over 1y
Location
SRI CORPORATION LIMITED
Trajectory
5y · 2020–NowFinancial sub-scores
Computed from 5 filingsConducts scientific and engineering research and development across areas including artificial intelligence, biosciences, education, computing, and advanced systems. Develops technologies,…
Serves government agencies and commercial organisations needing advanced R&D across AI, biosciences, education, health, climate, quantum, security and space, including partners commercialising…
Financial Health
HealthyHealthy
Location
SYNGENSYS LIMITED
Trajectory
4y · 2022–NowFinancial sub-scores
Computed from 4 filingsDevelops synthetic gene promoters and computational design tools to control gene expression for gene therapy, cell therapy and biologics manufacturing. Provides promoter libraries, tissue‑targeted…
Serves biotech and pharmaceutical organisations developing gene and cell therapies, biologics and biomanufacturing platforms, including teams working with tissue-targeted expression, CHO production…
Financial Health
HealthyHealthy · -59% CAGR over 3y
Location
S & S Electronics Ltd
Trajectory
3y · 2023–NowFinancial sub-scores
Computed from 3 filingsFinancial Health
DistressedDistressed · -18% CAGR over 2y
Location
Phoenix Biosciences Ltd
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsFinancial Health
DistressedDistressed · -16% CAGR over 4y
Location
South Lea Technology Limited
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsFinancial Health
StrongStrong · Hiring · 19% CAGR over 4y
Location
Noggin Analytics UK Ltd
Trajectory
2y · 2023–NowFinancial sub-scores
Computed from 2 filingsFinancial Health
DistressedDistressed · 0% CAGR over 1y
Location
ATOMIC PROGRAMMING LTD
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsFinancial Health
HealthyHealthy
Location
Seaview Sensing Limited
Trajectory
5y · 2020–NowFinancial sub-scores
Computed from 5 filingsFinancial Health
WeakWeak · 0% CAGR over 4y
Location
ELAROS 24/7 LIMITED
Trajectory
5y · 2022–NowFinancial sub-scores
Computed from 5 filingsFinancial Health
HealthyHealthy · -57% CAGR over 4y
Location
UCA Engineering Limited
Trajectory
3y · 2023–NowFinancial sub-scores
Computed from 3 filingsFinancial Health
WeakWeak
Location
Metalysis Ltd
Trajectory
5y · 2022–NowFinancial sub-scores
Computed from 5 filingsDevelops and operates solid-state electrolysis technology that converts metal oxides and ores into metal and alloy powders. Produces materials such as titanium, tantalum, aluminium‑scandium and…
Serves B2B customers in powder metallurgy, additive manufacturing and high-tech metal supply chains, including organisations needing rare or critical metal powders and novel alloys for advanced…
Financial Health
StableStable · Hiring · 27% CAGR over 4y
Location
ICEOTOPE TECHNOLOGIES LIMITED
Trajectory
2y · 2024–NowFinancial sub-scores
Computed from 2 filingsDevelops liquid cooling systems for data centre servers and high‑density computing, including solutions for AI, HPC, cloud and edge infrastructure. Designs chassis and fluid‑based cooling technology…
Serves B2B buyers running high-density compute infrastructure, including cloud service providers, telecom operators, enterprises, OEM/ODM server manufacturers, and HPC/AI data centre and edge…
Financial Health
WeakWeak · -14% CAGR over 1y
Location
Develops and manufactures membrane‑free electrolysers used to produce green hydrogen from water using renewable electricity. Provides hydrogen production technology and systems for industrial,…
Serves B2B organisations developing green hydrogen applications, including wastewater utilities, biomass and energy-from-waste operators, grid and data centre operators, life sciences facilities,…
Financial Health
Insufficient historyInsufficient history
Location
PRODUCTIVE MACHINES LIMITED
Trajectory
5y · 2020–NowFinancial sub-scores
Computed from 5 filingsDevelops software tools for CNC machining that optimise toolpaths, spindle speeds and feed rates to reduce chatter in milling. Provides applications and services that analyse machine settings to…
Sells to B2B machine shops and manufacturing businesses using CNC milling and CAM workflows, including machinists, shop-floor operators and manufacturing engineers.
Financial Health
WeakWeak · -61% CAGR over 3y
Location
LW SOLUTIONS LTD
Trajectory
5y · 2020–NowFinancial sub-scores
Computed from 5 filingsDesigns and manufactures laser wire processing systems for industrial and medical applications, including machines for wire stripping, cutting and micro‑drilling. Provides automated spool‑to‑spool…
Serves B2B manufacturing and engineering teams in medical devices, automotive, aerospace and defence, data centres and electronics, especially organisations with high-precision wire and cable…
Financial Health
HealthyHealthy · 0% CAGR over 4y
Location
SLS Coatings Limited
Trajectory
3y · 2022–NowFinancial sub-scores
Computed from 3 filingsManufactures precision laser optics including Fabry‑Perot etalons and high‑damage‑threshold optical components. Provides custom and standard thin‑film optical coatings for UV, visible and…
Serves B2B customers such as OEMs, optical product manufacturers, engineering teams and research organisations requiring precision laser optics, etalons and thin-film optical components.
Financial Health
WeakWeak · Hiring · 12% CAGR over 2y
Location
Castlewood Projects Ltd
Trajectory
1y · 2024–NowFinancial Health
Insufficient historyInsufficient history
Location
VOOV SURGICAL LTD
Trajectory
3y · 2023–NowFinancial sub-scores
Computed from 3 filingsDevelops flexible, printable graphene-based pressure and impact sensor systems and related intellectual property. Operates and supports IoT businesses that use these sensors to collect and analyse…
Serves B2B and public-sector organisations in wearables, industrial, defence, utilities and aerospace markets, including teams responsible for pressure or impact data collection.
Financial Health
DistressedDistressed · -90% CAGR over 2y
Location
Extreme Binary Limited
Trajectory
5y · 2020–NowFinancial sub-scores
Computed from 5 filingsFinancial Health
StableStable · 0% CAGR over 5y
Location
EDR&MEDESO LTD
Trajectory
4y · 2023–NowFinancial sub-scores
Computed from 4 filingsProvides engineering simulation software and related consultancy services, including sales, implementation, support and training for tools such as Ansys. Helps organisations model and test products…
Serves engineering and product development teams in aerospace, defence, energy, healthcare, high-tech, industrial equipment, marine, space, transportation, construction and consumer products, plus…
Financial Health
HealthyHealthy · Hiring · 12% CAGR over 3y
Location
PROTEA (2022) HOLDINGS LIMITED
Trajectory
3y · 2023–NowDesigns and supplies gas analysers and emissions monitoring systems for industrial, marine and environmental applications. Products include FTIR and infrared gas analysers, continuous emissions…
Serves B2B customers needing gas and emissions monitoring, including industrial process and combustion operators, incineration plants, marine and offshore companies, carbon capture projects, and…
Financial Health
Insufficient historyInsufficient history
Location
Britampco Limited
Trajectory
2y · 2023–NowFinancial sub-scores
Computed from 2 filingsFinancial Health
StableStable · 0% CAGR over 1y
Location
Industrial Software Limited
Trajectory
4y · 2022–NowFinancial sub-scores
Computed from 4 filingsProvides industrial automation software services including PLC, HMI and SCADA programming, control system design and modification, and backup of machine software. Also integrates plant-floor data…
Serves B2B industrial operators and manufacturers with production sites using PLC, HMI and SCADA control systems, including engineering, maintenance and operations teams.
Financial Health
StableStable · 0% CAGR over 3y
Location
Hiwatt Electronics Limited
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsFinancial Health
WeakWeak · -10% CAGR over 4y
Location
Manufactures and supplies equipment, components and digital systems for rail, transit and industrial transport sectors, including locomotive and freight car braking systems, electric motors, control…
Serves freight rail operators, public transit authorities and operators, mining companies, industrial manufacturers, marine operators and power generation customers globally.
Location
S3 ID GROUP LIMITED
Trajectory
3y · 2023–NowDevelops real-time location and identification systems that track personnel and assets in hazardous industrial environments. Provides electronic persons-on-board (ePOB), emergency mustering, and…
Sells to operators and HSE teams in safety-critical, hazardous industries, including offshore assets, onshore industrial sites, turnaround projects, and offshore wind facilities needing personnel…
Financial Health
Insufficient historyInsufficient history
Location
WD HYDROTECH LIMITED
Trajectory
4y · 2022–NowFinancial sub-scores
Computed from 4 filingsFinancial Health
WeakWeak
Location
V & V Health Innovations Ltd
Trajectory
4y · 2022–NowFinancial sub-scores
Computed from 4 filingsFinancial Health
StrongStrong
Location
RM Frobisher (1986) Ltd.
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsFinancial Health
WeakWeak · Hiring · 19% CAGR over 4y
Location
Fidelity Audio Limited
Trajectory
5y · 2021–NowFinancial sub-scores
Computed from 5 filingsFinancial Health
WeakWeak · 0% CAGR over 4y
Location
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How Sheffield Deep Tech companies work and how to sell to them
What they do
Revenue usually comes from intellectual property and delivery rather than pure licences. A Sheffield deep-tech firm may package patents, algorithms, materials know-how, sensing hardware or engineering methods into paid pilots, milestone-funded development work, enterprise licences, maintenance contracts and production supply. Hardware-led businesses may sell equipment, components or embedded systems alongside design, integration and support; software-led teams more often price by enterprise licence, usage, managed service or project milestones. Gross margins can vary widely because prototype work, certification, manufacturing partners and field deployment sit close to the core offer, rather than being after-sales extras.
Who they sell to
Their customers are usually organisations with technical risk on the balance sheet: manufacturers, utilities, infrastructure operators, health and care bodies, research-intensive groups and public-sector buyers. The day-to-day sponsor is often an engineering director, CTO, operations lead, clinical safety owner or cyber/security head, with procurement, finance and legal joining once the pilot becomes a contract. Contract values are usually tied to pilot scope, integration effort and assurance work, so buying can run for months rather than weeks. Routes to market tend to mix direct founder-led selling, partner introductions, grant-linked consortia and formal RFP processes.
What they buy
Most Sheffield deep-tech firms tend to spend on tools that help small technical teams look credible to cautious buyers. Common categories include CRM, proposal management, billing, project accounting, quality management, cybersecurity, device testing, cloud infrastructure, observability, data governance and product analytics. Hardware and engineering teams may also buy CAD, simulation, prototyping, lab services, certification advice, contract manufacturing support and facilities services. Professional services matter because commercial proof often depends on patents, standards evidence, public-sector procurement paperwork, grant claims, employment contracts, specialist recruitment and fractional finance or legal support.
Why and how to sell to them
Commercial pain usually appears when a team moves from research work to repeatable delivery, wins a first regulated customer, or needs to prove that a prototype can survive production, procurement and security review. Hiring a commercial lead, raising fresh capital, taking on a new public-sector framework, opening a production relationship or expanding across sites can all signal intent. Outbound messages tend to work better when they reduce validation burden, shorten evidence preparation, protect technical staff time or improve buyer assurance. Generic productivity claims are less likely to travel than proof that the offer lowers deployment risk.
How this list is built
Data sources
This list is built from UK Companies House filings, XBRL accounts data, and semantic analysis of each company's public website. Revenue and headcount figures come from the most recent filed accounts; where the company has not filed, values are estimated using a model trained on filed history and peer benchmarks and are labelled as estimates.
Classification
Rather than relying solely on SIC codes, Firmbase classifies each company semantically: the company's website is crawled, an AI model reads what the company actually sells, and the company is placed into the relevant industry and subsectors. SIC codes are used as one signal but not the only one. This means a company that registered under a generic SIC code but pivoted into (for example) fintech is correctly identified as fintech, not as its original SIC category.
Freshness
The underlying company data is refreshed from Companies House continuously; filings appear in the list within days of submission. The curated list ordering is regenerated when the underlying data moves meaningfully (company count changes by more than 5%, a new company enters the top-ranked segment, or the filed-revenue numbers for the top firms change). You can see the last-updated timestamp near the top of the page.
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Frequently asked questions
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